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Receptor activity-modifying proteins (RAMPs) are involved in changing the activity of G protein-coupled receptors. A range of important physiological functions have been recognised, particularly around food intake and glucose homeostasis. Given the rise of obesity and related conditions, understanding the associated fundamental biology is of huge importance.

This review article by Malcharek et al. highlights this set of proteins and explains their potential to be targeted as novel therapeutics. The authors take readers through the importance and prevalence of G protein-coupled receptors, which constitute the largest receptor family in our body, before moving on to more novel findings regarding the role of RAMPs in modulating their activity.

The section on methods for studying these interactions is of particular note, giving readers all the tools and background to push forward with this methodology in their own labs. The authors’ way of presenting novel approaches to the pathophysiology of both obesity and type 2 diabetes is one of the real benefits of this review, hopefully opening the door for new therapies to be developed.

Read the full article in Journal of Molecular Endocrinology 73 e240056 https://doi.org/10.1530/JME-24-0056