Ageing sees a widespread decline in biological function. This is driven by a range of molecular dysregulation leading to progressive failure of body organs and homeostatic systems. Though our understanding of these processes is partial, insights into ageing are advancing.

The glucocorticoid class of steroid hormones is fundamental for life and central to human health. Age-related increase in the pre-receptor generation of intracellular glucocorticoids, by 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), has been observed in a variety of cell and tissue types. However, its impact within the context of whole body functioning and vital physiological parameters remained untested.
Here, Morgan et al. used genetic ablation of 11BHSD1 in mice of young and aged cohorts to elevate our understanding of how glucocorticoids, and a lifetime’s exposure to them, impact tissue weight, tissue function and overall health. Using these data, they demonstrated that selective 11β-HSD1 inhibition may yet prove fruitful as a strategy in the search for the preservation of the human health-span.

Read the full article in Journal of Endocrinology.