Welcome to the first 2022 edition of The Endocrinologist, and my first as Editor! I must say a huge thank you to Helen Simpson, for stewarding the magazine through the ‘COVID chronical’ years – Helen, you’ll be missed. There have been further changes in the editorial team, with Doug Gibson coming to the end of his service – thank you Doug for your input (and laughter!) at our editorial board meetings. We warmly welcome Sophie Clarke, Gareth Nye and Venkatram Subramanian who join Louise Hunter on the editorial board, and are pleased to have Craig Doig as the new Associate Editor. Together, we look forward to bringing you cutting edge and provocative topics in endocrinology over the next eight editions!

With my research interests in reproductive endocrinology, I’m excited to introduce this edition jam-packed with features on the topic. With infertility affecting around one in seven couples, Sarah Martins Da Silva discusses male infertility and the potential of the CatSper ion channel as a novel therapeutic target. Brien Mehmet and Sofia Llahana provide a guide to the clinical management of Klinefelter syndrome, and Caroline Marquis shares a personal account of living with Turner’s syndrome. Steve Franks and Colin Duncan provide an update on energy balance and PCOS.

Moving to pregnancy, the role of the placenta in Barker’s theory of the developmental origins of disease are described by Gareth Nye and Phil Lowry and Miles Levy introduce theories and evidence surrounding the origins of morning sickness. From a clinical management perspective, Jackie Maybin provides a guide to specialist menstrual disorders services, Channa Jayasena and Richard Quinton summarise the new clinical guidelines for testosterone replacement therapy in men, and specialist nurse management of microprolactinomas is discussed by Laura Serban. With menopause a pertinent topic gaining increasing media traction and the MHRA launching a public consultation on making ‘Gina’ vaginal oestradiol tablets available from pharmacies (see the opinion piece by Sophie Clarke), Annice Mukherjee dispels myths and describes forward-thinking approaches to workplace and clinical management of menopause. Early Career Prize Lecturers, Elisa de Franco and Alessandro Prete, provide interesting summaries of their SfE BES 2021 presentations.

We hope you enjoy the issue.

KIM JONAS