Transcriptional coregulators act as gate keepers of gene expression, repressing or activating gene expression through modulation of transcription factor activity.

In this review, Nautiyal explores the multifaceted role of RIP140, an important transcriptional co-regulator for many physiological processes including reproduction and metabolism. The unique functional aspects of RIP140 actions are explored (it can function as both a coactivator and corepressor) and its roles within physiology are described.

Read the full article in Journal of Molecular Endocrinology 58 R147–R158